This article provides a brief overview of literature where regional hypertrophy was reported. It also discusses the basic science and application of regional hypertrophy training.

The squat is one of the most widely used exercises in resistance training programs. The aim of this narrative review was to analyze the effect of the squat on lower-limb muscle hypertrophy. Briefly, the available literature indicates that the squat is an effective exercise for inducing hypertrophy of the quadriceps, mainly the vastii, but also the rectus femoris, although to a reduced magnitude. Multiple lines of evidence suggest little to no hamstring hypertrophy from the back squat. Although the gluteus maximus clearly participates mechanically in the back squat, few longitudinal studies exist on the topic. The limited evidence available on this topic suggests deeper squats may be more hypertrophic for the gluteus maximus, and that, squat depth beyond 908 of knee flexion may not provide further hypertrophy of the knee extensors. Despite the popularity of the many squat variations, there are still controversies surrounding their hypertrophic potential for lower-limb musculature. Further studies are needed to investigate the hypertrophic effects of different squat variations, as well as differences in hypertrophy because of squat depth, stance, barbell position, and different squat apparatuses/machines.

This PTQ article discusses current research examining the relationship between training volume and muscle hypertrophy and provides guidelines for optimizing training outcomes. Visit NSCA online to read more on exercise science and sport performance.

Due to the principle of specificity, training should be tailored to the goal of the lifter in terms of the prioritization of strength, hypertrophy, health, and functional outcomes. If the goal is muscular hypertrophy, it may be beneficial to vary the repetition range, and to utilize a variety of loads and loading strategies in the pursuit of maximizing hypertrophy.

Lighter weights can translate to bigger muscles, Brad Schoenfeld says in this lecture from the NSCA's 2014 Personal Trainer Conference. Brad presents one of his latest studies, which looks at hypertrophy in trained subjects.

Jacob Wilson, PhD, CSCS,*D, presents at the NSCA's 2013 National Conference on the controversial topic of blood flow restriction training and its effects on strength and hypertrophy

This article provides eight important considerations when designing a program to optimally build the glutes.

This article discusses the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB) to help individuals better achieve their goals in muscle hypertrophy.

A study that investigated the effect of modified German volume training on muscular hypertrophy and strength concluded that the modified German volume training program is no more effective than performing five sets per exercise for increasing muscle hypertrophy and strength. To maximize hypertrophic training effects, it is recommended that 4 – 6 sets per exercise be performed.

The manipulation of resistance training (RT) variables is widely considered an essential strategy to maximize muscular adaptations. One variable that has received substantial attention in this regard is RT volume. This infographic provides evidence-based guidelines as to volume when creating RT programs designed to maximize muscle hypertrophy.